Molecular Classification
Post-translational modification, Chemical modification
Other Names
Protein Carbamylation, Protein Carbaminylation, Urea-derived post-translational modification, Cyanation of amino acids, Carbamoylation
Disease Roles
Chronic kidney diseaseCardiovascular diseasesAtherosclerosis

Amino Acid Carbamylation Overview

Amino acid carbamylation is a nonenzymatic post-translational modification where isocyanic acid reacts with free functional groups of amino acids or proteins. This alters protein structure and function and is implicated in aging and diseases like chronic kidney disease.

Mechanism of Action

N/A

Biological Functions

Protein modification
Altering protein structure
Modifying protein function
Molecular aging

Disease Associations

Chronic kidney disease
Cardiovascular diseases
Atherosclerosis
Accelerated aging
End-stage renal disease

Safety Considerations

  • Accumulation of carbamylated proteins can lead to organ dysfunction
  • May impair protein function and contribute to disease progression

Associated Biomarkers

Biomarker
Carbamylated proteins (e.g., in CKD)
Carbamylated albumin