Amino acid in stratum corneum

Amino acids in the stratum corneum refer to free amino acids that accumulate in the outermost layer of the epidermis as major components of the natural moisturizing factor (NMF). These amino acids—such as glycine, proline, lysine, arginine, alanine, asparagine, glutamine, and histidine—are critical for maintaining skin hydration, regulating barrier function, and preserving the structural integrity of the skin. Their concentration correlates with skin health, moisture retention, and age-related changes in skin barrier properties. Unlike classic molecular drug targets, these amino acids are not enzymes, receptors, transporters, or direct drug targets, but are biological effectors important in skin physiology and are supplemented by topical products to support skin health and treat dry skin or aging.

Other names

Natural moisturizing factor amino acidsNMF amino acidsfree amino acids in stratum corneum

Not relevant as target is not a receptor/enzyme. In skincare: topical delivery of amino acids increases skin hydration, supports barrier repair, and may enhance production of natural moisturizing factors.