Target intelligence / Profile preview

Amino Acid Supplementation (Peritoneally Absorbed)

Molecular classification
Nutritional Supplement, Therapeutic Intervention
01

Overview

Amino acid supplementation via the peritoneal route involves delivering amino acids directly into the peritoneal cavity, where they are absorbed through the peritoneal membrane into systemic circulation. This method is explored as an alternative or adjunct to intravenous and enteral nutrition, particularly in patients unable to tolerate oral or gastrointestinal feeding. Absorption is rapid, but requires co-administration of lipids to achieve full nutritional requirements.

Other names
Intraperitoneal Amino Acid SupplementationPeritoneal Amino Acid InfusionPeritoneal Amino Acid Nutrition
02

Mechanism of action

Provides amino acids directly into the peritoneal cavity for absorption into systemic circulation, bypassing first-pass hepatic metabolism to be used for protein synthesis and other metabolic functions.

03

Biological functions

Nutritional SupportProvision of Amino Acids for Protein SynthesisMetabolic Substrate
04

Disease associations

MalnutritionProtein DeficiencyNutritional Support in Renal Failure (Peritoneal Dialysis)Patients with Compromised Oral/Enteral/Parenteral Nutrition
05

Safety considerations

Infection (Peritonitis)Catheter-related complicationsFluid overloadElectrolyte imbalancesInsufficient caloric provision (requires supplemental fat source)Long-term efficacy not fully established
06

Biomarkers

Plasma Amino Acid LevelsNitrogen BalancePrealbuminAlbumin

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