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Amino Acid Transporter (AAT)
- Target
- AAT
- Molecular classification
- Transporter, Solute Carrier (SLC) Family
01
Overview
Amino acid transporters are membrane-bound proteins responsible for the movement of amino acids across cellular membranes. They are essential for supplying cells with amino acids required for protein synthesis, metabolism, signaling, and other physiological processes. They belong primarily to the solute carrier (SLC) family and exhibit diverse substrate specificities, mechanisms of action, and tissue distributions. Dysregulation of these transporters is implicated in various diseases, including metabolic disorders and cancer.
- Other names
- Solute Carrier (SLC) Family Amino Acid TransportersASCT2/SLC1A5ATB^0,+/SCL6A14y+ system transporters4F2hc/asc-1 (SLC3A2/SCL7A10)
02
Mechanism of action
Varies by specific transporter: Na+-dependent cotransport, H+-coupled symport, antiport/exchange, facilitated diffusion.
03
Biological functions
Amino acid transportNutrient uptakeCellular homeostasisProtein synthesisMetabolismCell signaling
04
Disease associations
Metabolic disordersCancerIminoglycinuria
05
Safety considerations
Off-target effects due to broad substrate specificity of some transportersDysregulation leading to metabolic imbalancesPotential for drug resistance in cancer cells
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