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Target intelligence / Profile preview
Amino Acid Transporter System L (System L)
- Target
- System L
- Molecular classification
- Transporter
01
Overview
System L is a key sodium-independent transporter mediating cellular uptake/exchange of large neutral essential amino acids. Its major isoform LAT1 forms a heterodimer with CD98/4F2hc at cell membranes. Highly expressed at physiological barriers like blood-brain barrier—and upregulated in many cancers—it serves both vital nutritional roles and offers opportunities for targeted drug delivery or therapeutic intervention against malignancies.
- Other names
- Large Neutral Amino Acid Transporter
02
Mechanism of action
Inhibition of amino acid transport, Facilitation of drug transport
03
Biological functions
Amino acid transportNutrient supplyDrug delivery
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to broad substrate specificityDisruption of normal amino acid homeostasis
06
Interacting drugs
l-DOPA
2 more in the full profile.
07
Biomarkers
LAT1 expression levels in tumors
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