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Aminohydrolase

Molecular classification: Enzyme, Amidase Signature Family, Amidohydrolase Superfamily, Serine Hydrolase

Overview

Aminohydrolases are a class of enzymes that catalyze the hydrolysis of amide bonds, converting amides into their corresponding acids and ammonia or amines. Key examples include Fatty Acid Amide Hydrolase (FAAH), which degrades endogenous fatty acid amides like anandamide and oleamide. They play critical roles in regulating pain sensation, sleep induction, inflammation, and anxiety responses. Inhibition of aminohydrolases is being explored for therapeutic applications.

Other names: Amidohydrolase

Mechanism of action

Inhibition of aminohydrolase activity, leading to increased levels of endogenous substrates.

Biological functions

Hydrolysis of amide bondsRegulation of bioactive lipid levelsEndocannabinoid system modulation

Disease associations

PainAnxiety disordersInflammationNeurodegenerative disease

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