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Target intelligence / Profile preview
Aminoimidazole Carboxamide Ribonucleotide Transformylase (AICART)
- Target
- AICART
- Molecular classification
- Enzyme, Transferase
01
Overview
AICART is a key enzyme in the de novo purine biosynthesis pathway, catalyzing the transfer of a formyl group from 10-formyltetrahydrofolate to AICAR. This reaction is essential for generating IMP. In humans, AICART activity resides within the bifunctional enzyme ATIC. Inhibition of AICART has therapeutic implications in cancer chemotherapy and anti-inflammatory therapy.
- Other names
- AICAR transformylaseaminoimidazole-4-carboxamide ribonucleotide formyltransferaseATASEATIC (when referring to the bifunctional enzyme with IMP cyclohydrolase activity)
02
Mechanism of action
Inhibition of AICART, leading to accumulation of upstream intermediates and disruption of purine biosynthesis.
03
Biological functions
Purine biosynthesisMetabolic regulation
04
Disease associations
CancerInflammation
05
Safety considerations
Impaired cell proliferationSide effects related to antifolate therapy
06
Interacting drugs
Methotrexate
3 more in the full profile.
07
Biomarkers
ZMP/AICA-ribotide
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