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Aminopeptidase B
- Molecular classification
- Enzyme, Metallopeptidase, M1 family metallopeptidase
01
Overview
Aminopeptidase B (AP-B) is a zinc-dependent exopeptidase enzyme that selectively removes basic residues—specifically arginine (Arg) and lysine (Lys)—from the N-terminus of peptide substrates. It plays a crucial role in the final stages of precursor processing mechanisms, neuropeptide metabolism, and the regulation of bioactive peptides. AP-B is widely distributed across various tissues and intracellular/extracellular locations. Its activity is regulated by zinc ion concentration.
- Other names
- Arylamidase IIArginine aminopeptidaseArginyl aminopeptidaseCl–-activated arginine aminopeptidaseCytosol aminopeptidase IVL-arginine aminopeptidase
02
Mechanism of action
Inhibition of aminopeptidase B activity
03
Biological functions
Neuropeptide processingHormone processingPrecursor peptide maturationProteolysis
04
Interacting drugs
Bestatin (ubenimex)
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