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Target intelligence / Profile preview
Aminopeptidase N (APN)
- Target
- APN
- Molecular classification
- Enzyme, Metalloprotease, Type II transmembrane protein
01
Overview
Aminopeptidase N (APN), also known as CD13, is a multifunctional, membrane-bound zinc metalloprotease involved in peptide metabolism, antigen processing, cell adhesion, and other biological processes. It is a therapeutic target for cancer and inflammatory disorders and also serves as a viral entry receptor.
- Other names
- CD13Alanyl aminopeptidaseANPEPGP150LAP1P150PEPNAP-MhAPN
02
Mechanism of action
Enzyme inhibition
03
Biological functions
Peptide metabolism/degradationAntigen processing/trimmingCell adhesion/motilityExtracellular matrix degradationRegulation of immune responsesSignal transduction
04
Disease associations
CancerInflammationInfection
05
Safety considerations
Potential for off-target effects due to broad expressionInhibition may disrupt normal physiological functions
06
Interacting drugs
Bestatin
07
Biomarkers
Myeloid cell marker
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