Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ammonia (NH₃)
- Target
- NH₃
- Molecular classification
- Inorganic Compound, Gas, Pnictogen Hydride, Weak Base
01
Overview
Ammonia (NH₃) is a colorless gas with a pungent odor, serving as a fundamental component in biological systems (nitrogen cycle) and various industrial processes (fertilizers, chemical synthesis). While essential in certain biological pathways, elevated levels can be toxic. It is not typically considered a direct therapeutic target, but rather a molecule whose levels are managed in the context of certain diseases.
- Other names
- Azane
02
Mechanism of action
Lactulose: Acidifies the colon, promoting conversion of ammonia to ammonium, which is then excreted. Rifaximin: Reduces ammonia production by decreasing the number of ammonia-producing bacteria in the gut. Benzoate: Combines with ammonia to form hippurate, which is excreted.
03
Biological functions
Nitrogen CycleMetabolic Waste Product (in some organisms)pH regulation (indirectly)
04
Disease associations
Hepatic Encephalopathy (elevated levels)Uremia (elevated levels)
05
Safety considerations
Neurotoxicity (at high concentrations)Respiratory irritationCorrosive to tissuesEnvironmental hazard
06
Interacting drugs
Lactulose
2 more in the full profile.
07
Biomarkers
Blood ammonia levels (diagnosis and monitoring of hyperammonemia)
Beyond the preview
Go deeper on Ammonia (NH₃).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ammonia (NH₃).