Gosset Molecular Classification
Inorganic ion, Polyatomic ion
Other Names
Ammonium cation, Tetrahedral ammonium
Disease Roles
Ammonium Ion Overview
The ammonium ion (NH₄⁺) is a polyatomic cation formed by the protonation of ammonia. It plays a crucial role in nitrogen metabolism and acid-base balance in biological systems. While not a direct therapeutic target in the traditional sense, its levels are carefully monitored and managed in conditions like hepatic encephalopathy and urea cycle disorders. Treatments aim to reduce ammonia production or absorption.
Mechanism of Action
Biological Functions
Nitrogen metabolism
Acid-base balance
Disease Associations
Hepatic encephalopathy (related to ammonia levels)
Urea cycle disorders (related to ammonia levels)
Safety Considerations
- Hyperammonemia (toxic levels of ammonia in the blood)
- Acidosis
Interacting Drugs
Lactulose (reduces ammonia absorption)
Rifaximin (reduces ammonia production in the gut)
Associated Biomarkers
| Biomarker |
|---|
| Plasma ammonia levels |