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Amorphous calcium phosphate (ACP)
- Target
- ACP
- Molecular classification
- Other
01
Overview
Amorphous calcium phosphate (ACP) is a non-crystalline, metastable form of calcium phosphate that serves as a precursor to hydroxyapatite and supports bone and dental mineralization by providing bioavailable calcium and phosphate ions. It is used as a biomaterial but is not a direct therapeutic target.
- Other names
- Amorphous calcium phosphateACPBiogenic amorphous calcium phosphate (BACP)Synthetic amorphous calcium phosphate (SACP)
02
Biological functions
Bone mineralizationPrecursor to hydroxyapatite formationReservoir for calcium and phosphate ionsRemineralization of dentin
03
Disease associations
Other (tissue engineering, bone repair, dental applications)
04
Safety considerations
Rapid dissolution leading to burst release of ions (in synthetic forms)Potential pH fluctuations and osmotic stressTransformation to crystalline phases unless stabilized
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