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Target intelligence / Profile preview
AMP–activated protein kinase catalytic subunit alpha 1 (AMPKα1)
- Target
- AMPKα1
- Molecular classification
- Serine/threonine protein kinase, Enzyme
01
Overview
AMPKα1 is the catalytic α1 subunit of the heterotrimeric enzyme complex known as AMP-activated protein kinase (AMPK). AMPK functions as a central regulator of cellular energy homeostasis in eukaryotes. It is activated in response to increased cellular AMP/ATP or ADP/ATP ratios, which signal energy stress within the cell. It regulates multiple metabolic processes through phosphorylation of downstream targets.
- Other names
- 5'-AMP-activated protein kinase catalytic subunit alpha-1Protein kinase, AMP-activated, alpha 1PRKAA1
02
Mechanism of action
Activates catabolic pathways and inhibits anabolic pathways by phosphorylating downstream targets.
03
Biological functions
Cellular energy homeostasis regulationRegulation of glucose uptakeRegulation of fatty acid oxidationMitochondrial biogenesis regulationmTORC1 pathway inhibition
04
Disease associations
Type II diabetes/metabolic syndromeCardiovascular diseasesNeurodegenerative disordersVarious cancers
05
Safety considerations
Discrimination between disease involvement for each isoform (α1 vs α2) remains challenging.Potential off-target effects due to widespread expression and regulatory roles.
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