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Target intelligence / Profile preview
AMP-activated protein kinase alpha (None)
- Target
- None
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase
01
Overview
AMP-activated protein kinase (AMPK) is a central regulator of cellular and whole-body energy homeostasis. It functions as an energy sensor, activated by increases in the cellular AMP/ATP ratio, and acts to restore energy balance. The alpha subunit (AMPKα) serves as the catalytic core of this heterotrimeric enzyme complex, phosphorylating key metabolic enzymes to inhibit anabolic processes and promote catabolic pathways.
02
Mechanism of action
Direct activation of AMPK by small molecules or indirect activation through modulation of upstream regulators (e.g., LKB1) and/or AMP/ATP ratio.
03
Biological functions
Energy homeostasis regulationMetabolic regulationAutophagy regulationMitochondrial biogenesisAntioxidant defense
04
Disease associations
Type 2 Diabetes MellitusCancer
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