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Target intelligence / Profile preview
AMP-activated protein kinase alpha catalytic subunit isoform alpha-1 (AMPKA1)
- Target
- AMPKA1
- Molecular classification
- Enzyme, Serine/threonine protein kinases
01
Overview
AMPKA1 is the catalytic subunit of the heterotrimeric AMP-activated protein kinase (AMPK) complex, a central regulator of cellular energy homeostasis. It is activated by increased AMP/ATP ratio or calcium-mediated signaling and phosphorylates numerous substrates to regulate metabolism. Dysregulation or mutation in AMPKA1/PRKAA1 has been implicated in several diseases.
- Other names
- PRKAA1
02
Mechanism of action
Activation via phosphorylation at threonine 172 (Thr172). Direct activation by small molecules.
03
Biological functions
Energy homeostasis regulationRegulation of metabolismRegulation of autophagyRegulation of cell growth/proliferationRegulation of cell polarityTranscriptional regulationChromatin structure modificationProtection against metabolic stress
04
Disease associations
Diabetes/metabolic syndromeCardiovascular diseasesNeurodegenerative disordersVarious cancers
05
Safety considerations
Overlapping functions of AMPKα isoforms make it difficult to discriminate disease involvement.Potential for off-target effects due to broad substrate specificity.
06
Interacting drugs
A769662
1 more in the full profile.
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