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Target intelligence / Profile preview
AMP-activated Protein Kinase Family Member 5 (ARK5)
- Target
- ARK5
- Molecular classification
- Enzyme, Serine/Threonine Kinase, AMPK Family
01
Overview
AMP-activated Protein Kinase Family Member 5 (ARK5), also known as NUAK1, is a serine/threonine kinase belonging to the AMPK family. It plays a crucial role in cellular energy homeostasis by sensing AMP:ATP ratios and regulating metabolic pathways. ARK5 is implicated in cancer cell survival, migration, and invasion, particularly under metabolic stress conditions. Elevated ARK5 expression is observed in pancreatic adenocarcinoma and correlates with poor prognosis.
- Other names
- NUAK1KIAA0537
02
Mechanism of action
Inhibition of acetyl-CoA carboxylase (ACC), Akt-dependent pathways
03
Biological functions
Energy homeostasisMetabolic regulationCell survivalCell migrationGlucose uptakeFatty acid synthesis inhibition
04
Disease associations
CancerPancreatic adenocarcinoma
05
Safety considerations
Potential for off-target effects due to kinase activity
06
Biomarkers
ARK5 expression level in pancreatic adenocarcinoma
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