Target intelligence / Profile preview

AMP-dependent Protein Kinase (AMPK)

Target: AMPK
Molecular classification: Enzyme, Serine/threonine kinase

Overview

AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that functions as a central regulator of cellular and whole-body energy homeostasis. It acts as an energy sensor, activated by increases in the AMP/ATP or ADP/ATP ratio, which typically occur during metabolic stress or increased ATP consumption.

Mechanism of action

AMPK activation to promote catabolic pathways and inhibit anabolic pathways.

Biological functions

Energy sensingMetabolic regulationCell growth controlAutophagy

Disease associations

Type 2 diabetesObesityCancerNeurodegenerative diseaseMetabolic disorders

Interacting drugs

A769662

1 more in the full profile.

Beyond the preview

Go deeper on AMP-dependent Protein Kinase (AMPK).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on AMP-dependent Protein Kinase (AMPK).

Explore the full profile