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Target intelligence / Profile preview
AMP-dependent protein kinase catalytic subunit alpha (AMPK)
- Target
- AMPK
- Molecular classification
- Enzyme, Serine/threonine kinase
01
Overview
AMP-activated protein kinase (AMPK) is a central regulator of cellular and whole-body energy homeostasis in eukaryotes. It acts as a metabolic sensor, activated by increased AMP/ADP levels relative to ATP, which typically occurs during energy stress or high ATP consumption. AMPK activation shifts metabolism from anabolic (energy-consuming) to catabolic (energy-generating) pathways, helping restore cellular energy balance.
02
Mechanism of action
Indirect AMPK activation through inhibition of mitochondrial complex I.
03
Biological functions
Energy homeostasisRegulation of glucose uptakeRegulation of fatty acid oxidationRegulation of fatty acid synthesisRegulation of cholesterol synthesisRegulation of gluconeogenesisMitochondrial biogenesisAutophagy
04
Disease associations
Type 2 diabetes mellitusObesity/metabolic syndromeCardiovascular diseaseCancerNeurodegenerative diseases
05
Interacting drugs
Metformin
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