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Target intelligence / Profile preview
AMP-related protein kinase 5 (ARK5)
- Target
- ARK5
- Molecular classification
- Serine/threonine kinase, AMPK-related kinase
01
Overview
AMP-related protein kinase 5 (ARK5), also known as NUAK1, is a serine/threonine kinase belonging to the AMPK-related kinase family. It plays a role in cellular stress responses, regulating the localization of RNA-binding proteins and modulating apoptosis. ARK5 is involved in energy homeostasis and may represent a therapeutic target for diseases characterized by aberrant cell death or survival signaling.
- Other names
- NUAK1
02
Mechanism of action
Phosphorylation of target proteins, e.g., hnRNP A1, leading to altered protein localization and activity.
03
Biological functions
Regulation of RNA-binding protein localizationModulation of apoptosisStress responseEnergy homeostasis
04
Disease associations
CancerMetabolic disorders
05
Safety considerations
Potential off-target effects due to structural similarity with other kinases.
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