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Target intelligence / Profile preview
Amphiregulin (AREG)
- Target
- AREG
- Molecular classification
- Epidermal Growth Factor family, Growth factor, Transmembrane glycoprotein
01
Overview
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family of proteins. Synthesized as a transmembrane glycoprotein, its extracellular domain is cleaved to release a mature, soluble form that acts as a ligand for the Epidermal Growth Factor Receptor (EGFR). AREG stimulates the proliferation of various cell types, including keratinocytes, epithelial cells, and fibroblasts. It plays a crucial role in mammary gland development, tissue repair, and immunoregulation. Elevated AREG expression has been implicated in cancer progression and tumor immune evasion.
- Other names
- AREG GeneAmphiregulin, humanEGF-like growth factor
02
Mechanism of action
Binds to and activates the Epidermal Growth Factor Receptor (EGFR), leading to downstream signaling through pathways such as PI3K-Akt.
03
Biological functions
Cell proliferationCell differentiationTissue repairImmunoregulationSignaling via EGFRMammary gland development
04
Disease associations
Cancer progressionTumor immunityTissue injury responseInflammation
05
Safety considerations
Potential to promote tumor growthMay enhance tumor immune evasion
06
Biomarkers
Upregulated AREG expression in cancer cells
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