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AMPK and mitochondrial complex I

Overview

AMPK and mitochondrial complex I refers to the interplay between energy sensing by AMPK and mitochondrial ATP production by complex I. AMPK is commonly activated in states of mitochondrial dysfunction or direct complex I inhibition (e.g., by metformin or rotenone). The interaction of these molecular entities is crucial for cellular adaptation to energetic stress, regulation of mitochondrial quality, and pharmacological intervention in metabolic diseases[2][1][5].

Mechanism of action

The combined phrase refers to the interplay where AMPK is activated in response to mitochondrial dysfunction or direct complex I inhibition, such as by metformin or rotenone.

Biological functions

Interplay between energy sensing and ATP productionCellular adaptation to energetic stressRegulation of mitochondrial quality

Disease associations

Metabolic diseases

Interacting drugs

Metformin

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