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Target intelligence / Profile preview
NUAK family SNF1-like kinase 1 (ARK5)
- Target
- ARK5
- Molecular classification
- Serine/threonine-protein kinase, AMPK-related kinase, Enzyme
01
Overview
NUAK family SNF1-like kinase 1 (ARK5/NUAK1) is a serine/threonine-protein kinase involved in regulating cellular senescence, cell adhesion, DNA damage response, and cell survival under stress conditions. It is activated by phosphorylation and its overexpression is associated with various cancers, promoting tumor progression and metastasis.
- Other names
- NUAK1AMPK-related protein kinase 5SNF1-like kinase 1OMPHK1KIAA0537
02
Mechanism of action
Kinase inhibition
03
Biological functions
Regulation of cellular senescence and ploidyControl of cell adhesionDNA damage responsePromoting cell survival during nutrient deprivationRegulation of myosin protein phosphatase 1 (PP1) complexPhosphorylation of p53/TP53Inhibition of caspase activationInhibition of death receptor signaling pathways
04
Disease associations
CancerMultiple myelomaMantle cell lymphomaMetastasisGenomic instability (aneuploidy)
05
Safety considerations
Potential for off-target effects due to kinase family conservationTumor promotion in specific contextsResistance to apoptosis
06
Interacting drugs
WZ4003
2 more in the full profile.
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