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Target intelligence / Profile preview
Amylin 1 Receptor (AMY1)
- Target
- AMY1
- Molecular classification
- G protein-coupled receptor, Receptor, Class B GPCR, Heterodimeric receptor
01
Overview
The Amylin 1 receptor (AMY1) is a member of the amylin receptor family, which are heterodimeric complexes formed by the calcitonin receptor (CTR) and a receptor activity-modifying protein 1 (RAMP1). AMY1 specifically consists of CTR paired with RAMP1. Activation leads to cAMP production via Gs-protein coupling and plays a key role in regulation of gastric emptying, food intake, satiety, and glycemic control.
- Other names
- Amylin receptor subtype 1CTR/RAMP1 receptor complexCalcitonin Receptor/RAMP1 complex
02
Mechanism of action
Activation leads to cAMP production via Gs-protein coupling
03
Biological functions
Inhibition of gastric emptyingRegulation of food intakePromotion of satietyRegulation of glycemic controlSignal transduction
04
Disease associations
ObesityDiabetesMigraineAlzheimer's disease
05
Interacting drugs
Amylin
4 more in the full profile.
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