Amylin receptor 1 (AMY1R) (AMY1R)

The Rat Amylin receptor 1 (AMY1R) is a functional heterodimeric G protein-coupled receptor formed by the association of the Calcitonin receptor (CTR) and the Receptor Activity-Modifying Protein 1 (RAMP1) [1][2]. In rats, this receptor complex is primarily expressed in the hindbrain, specifically the area postrema, where it mediates the anorectic effects of amylin, a peptide hormone co-secreted with insulin from pancreatic beta cells [3]. Activation of AMY1R leads to a reduction in food intake, slowing of gastric emptying, and suppression of postprandial glucagon secretion, making it a critical regulator of energy balance and glucose metabolism [2][4]. Due to its role in appetite control, AMY1R is a significant therapeutic target for the treatment of obesity and type 2 diabetes [5]. Synthetic amylin analogues, such as pramlintide and the long-acting cagrilintide, utilize this pathway to improve glycemic control and induce weight loss [5]. Understanding the specific pharmacology of the rat variant is essential for preclinical development of metabolic disease therapies [3].

Other names

AMY1CTR/RAMP1 complexCalcitonin receptor/Receptor activity-modifying protein 1 complexRat AMY1 receptor

Agonism of the AMY1R complex activates Gs-mediated signaling, increasing intracellular cAMP levels in the area postrema of the hindbrain, which induces satiety and slows gastric emptying.