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Target intelligence / Profile preview
Amyloid beta 1-42 (Aβ42)
- Target
- Aβ42
- Molecular classification
- Peptide
01
Overview
Amyloid beta 1–42 is an intrinsically disordered peptide prone to forming toxic aggregates central to Alzheimer’s pathology. Its structural transitions—from flexible monomer through various oligomeric intermediates into highly ordered cross-beta sheet filaments—underlie both its biological activity and pathogenicity within neural tissue.
- Other names
- Amyloid beta 42Abeta 42Aβ1-42
02
Mechanism of action
Aggregation inhibition (potential therapeutics)
03
Biological functions
Neuronal growth and adhesion (APP)Formation of amyloid plaquesNeurotoxicity
04
Disease associations
Alzheimer's diseaseNeurodegenerative disease
05
Safety considerations
Non-selective targeting may disrupt physiological APP functions.Immunotherapies may cause amyloid-related imaging abnormalities (ARIA).
06
Biomarkers
Cerebrospinal fluid Aβ42 levelsAmyloid PET imaging
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