Amyloid beta A4 precursor protein-binding family A member 1 (APBA1)

Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, also known as X11 or MINT1) is a neuronal adaptor protein primarily expressed in the brain, where it interacts with the C-terminus of the amyloid precursor protein (APP). APBA1 stabilizes APP at the cell surface and inhibits its proteolytic cleavage, reducing generation of amyloid-beta peptide, which is implicated in the pathology of Alzheimer’s disease. As a member of the X11/Mint family, APBA1 is a multidomain scaffold protein containing a PTB domain and PDZ domains, enabling formation of multiprotein complexes involved in synaptic vesicle exocytosis, neuronal signaling, and synaptic plasticity. APBA1 is implicated in coupling vesicle exocytosis to cell adhesion at synapses, further influencing neurotransmitter release and neuronal connectivity. Loss or alteration of APBA1 disrupts these processes and is linked to altered APP processing, beta-amyloid accumulation, and synaptic dysfunction relevant to neurodegenerative disease, particularly Alzheimer’s disease.

Other names

X11X11alphaMINT1Mint-1Neuron-specific X11 proteinNeuronal Munc18-1-interacting protein 1LIN10D9S411EAdapter protein X11alpha