Amyloid beta A4 precursor protein-binding family A member 3 (APBA3)

Amyloid beta A4 precursor protein-binding family A member 3 (APBA3) is an adapter protein of the X11/Mint family that interacts with the cytoplasmic domain of the Alzheimer’s disease amyloid precursor protein (APP) and plays important roles in signal transduction, cellular metabolism, and inflammation. In macrophages, APBA3 (also known as Mint3) binds and sequesters FIH-1, leading to enhanced HIF-1 activity under normoxic conditions, promoting glycolytic ATP production and supporting energy-intensive immune functions such as cytokine production and chemotaxis. APBA3 thereby acts as a nodal mediator linking metabolic regulation with immune responses and cell motility. It is implicated both in neurodegenerative conditions (Alzheimer’s disease) and cancer progression, and is regarded as a potential therapeutic target for modulating aberrant macrophage activity in diseases involving inflammation and metastasis.

Other names

MINT3X11L2Mint-3X11gammaAdapter protein X11gammaNeuron-specific X11L2 proteinNeuronal Munc18-1-interacting protein 3X11-like 2MGC:15815amyloid-beta A4 precursor protein-binding family A member 3X11-like 2 proteinPTB-bearing proteinamyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)mint3amyloid beta precursor protein binding family A member 3lin-10

Inhibits factor inhibiting HIF-1 (FIH-1) to enhance HIF-1 activity in macrophages; Modulates processing and binding of amyloid precursor protein (APP)