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Target intelligence / Profile preview
Amyloid beta aggregate
- Molecular classification
- Protein aggregate
01
Overview
Amyloid beta aggregates are misfolded protein assemblies implicated as central drivers in Alzheimer’s disease pathogenesis. Their structural diversity—from soluble oligomers to insoluble plaques—underpins their varied biological effects. Therapeutic strategies focus on reducing their formation or promoting their clearance due to their established role in neurodegeneration associated with AD pathology.
- Other names
- Aβ aggregatesAmyloid plaquesAbeta oligomersAmyloid beta oligomersAmyloid beta fibrils
02
Mechanism of action
Inhibition of production, prevention of aggregation/promotion of disaggregation, promotion of clearance
03
Biological functions
Disruption of cell-to-cell communicationInduction of inflammatory responsesImpairment of synaptic functionNeuronal deathNeurotoxicity
04
Disease associations
Alzheimer's disease
05
Safety considerations
Vasogenic edemaAmyloid-related imaging abnormalities (ARIA)Potential for off-target effects of secretase inhibitors
06
Interacting drugs
Secretase inhibitors
2 more in the full profile.
07
Biomarkers
Aβ(1-40) levelsAβ(1-42) levelsPlaque load (imaging)CSF Aβ levels
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