Amyloid beta peptide aggregate

Amyloid beta (Aβ) peptide aggregates are assemblies of Aβ peptides, short fragments derived from the amyloid precursor protein (APP). These aggregates are central to Alzheimer’s disease pathology, accumulating as extracellular plaques and contributing to neurodegeneration. They exist in various forms, including oligomers, protofibrils, and fibrils, with oligomers being particularly neurotoxic. Therapeutic strategies focus on inhibiting aggregation, promoting clearance, and blocking toxic interactions with neuronal receptors.

Other names

Aβ aggregatesAmyloid plaquesAbeta oligomersAβ fibrilsAmyloid beta oligomersAmyloid beta fibrils

Inhibition of aggregation; promotion of clearance/degradation; blocking toxic interactions with neuronal receptors; reduction of Aβ production.