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Target intelligence / Profile preview
Amyloid beta peptide 1-40 (Aβ(1-40))
- Target
- Aβ(1-40)
- Molecular classification
- Peptide
01
Overview
Amyloid beta peptide 1-40 (Aβ(1-40)) is a 40-amino acid peptide derived from the amyloid precursor protein (APP). It is a major component of amyloid plaques in Alzheimer's disease and is implicated in neurotoxicity and neurodegeneration through aggregation and fibril formation.
02
Mechanism of action
Aggregation inhibition
03
Biological functions
AggregationNeurotoxicityPlaque formation
04
Disease associations
Alzheimer's diseaseCerebral amyloid angiopathyNeurodegenerative disease
05
Safety considerations
ImmunogenicityOff-target effectsDelivery to the brain
06
Biomarkers
Aβ(1-40) levels in cerebrospinal fluidAβ(1-40) levels in plasmaAmyloid plaques in brain imaging
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