Amyloid beta precursor protein binding family B member 1 (APBB1)

Amyloid beta precursor protein binding family B member 1 (APBB1, also known as FE65) is a nuclear-localized adaptor protein of the Fe65 protein family. It interacts directly with the cytoplasmic tail of amyloid precursor protein (APP) and is involved in the transcriptional regulation of genes, modulation of apoptosis, and cell cycle progression. APBB1 is proposed to play an important role in Alzheimer’s disease pathogenesis due to its association with APP and effects on amyloid processing and nuclear signaling. It is also implicated in learning, memory, and the maintenance of neuronal and muscle functions[1][2][3][11]. Multiple alternatively spliced isoforms exist, with some differences in their nuclear signaling potential. APBB1 interacts with various partners including APP, APLP2, transcription factor CP2/LSF/LBP1, and LRP1, supporting its role as a key signal integration molecule in the central nervous system[1][3][8][11].

Other names

FE65RIRProtein Fe65FE65a2Amyloid-beta A4 precursor protein-binding family B member 1adaptor protein FE65stat-like protein

null (adapter protein; drugs modulating APP processing may be indirectly relevant, but no direct targeting mechanism described)