Amyloid beta precursor protein binding family B member 2 (APBB2)

Amyloid beta precursor protein binding family B member 2 (APBB2) is an adaptor protein containing two phosphotyrosine binding (PTB) domains, which facilitate protein interactions involved in signal transduction. APBB2 interacts specifically with the cytoplasmic domains of amyloid beta (A4) precursor protein (APP) and APP-like protein 2, and plays a key role in the regulation of APP processing and amyloid-beta production. Overexpression of APBB2 increases amyloid-beta peptide production, a hallmark of Alzheimer’s disease pathology, and gene variants have been linked to late-onset Alzheimer’s and severe cognitive impairment. Beyond its role in neurodegeneration, APBB2 participates in processes such as actin remodeling, nuclear signaling, DNA repair, calcium homeostasis, apoptosis regulation, synaptic function, and glucose metabolism. It is not a classical receptor, enzyme, or transporter, but a multi-domain adaptor protein central to several signaling and neuronal pathways

Other names

Fe65-likeFE65LFE65L1Amyloid-beta (A4) precursor protein-binding family B member 2Protein Fe65-like 1Rirl1TR2LZfra2310007D03RIKDKFZp434E033RGD1562438MGC35575

no drugs specifically target APBB2 directly; mechanisms may involve modulation of APP processing and amyloid-beta production, but no direct therapeutic MOA documented