Amyloid beta precursor protein binding protein 2 (APPBP2)

Amyloid beta precursor protein binding protein 2 (APPBP2) is a highly conserved, multi-domain protein that acts as a substrate recognition receptor within the Cullin 2-RING ubiquitin ligase complex (CRL2). It specifically recognizes C-terminal R-x-x-G degron motifs in substrate proteins, leading to targeted ubiquitin-mediated degradation. APPBP2 interacts with microtubules, regulates the transport and processing of beta-amyloid precursor protein—a protein implicated in Alzheimer's disease—and is linked to cancer biology. Structural insight has established its role in protein turnover and provided a foundation for the design of small-molecule ligands such as PROTACs for selective degradation of pathological targets[2][4][5]. Overexpression of APPBP2 has clinical relevance as a biomarker in several cancer types.

Other names

APPBP2Amyloid beta precursor protein binding protein 2Amyloid precursor protein binding protein 2Roadblock-1

Drugs or PROTACs targeting APPBP2 typically function by promoting ubiquitin-mediated degradation of proteins via recognition of C-degron motifs