Amyloid Beta Protein Aggregate (Aβ Aggregate)

Amyloid beta (Aβ) protein aggregates are misfolded assemblies of the amyloid beta peptide, a central molecule in the pathology of Alzheimer’s disease (AD). These aggregates form through a complex process involving monomeric Aβ peptides assembling into soluble oligomers, protofibrils, and eventually insoluble fibrils that deposit as plaques in brain tissue. The aggregation is highly polymorphic and can result in structures with diverse morphologies and toxicities. Soluble oligomeric forms are considered particularly neurotoxic, disrupting synaptic function before plaque deposition occurs. Aggregates mediate cell-to-cell transmission within the brain and induce neuroinflammation by activating microglia.

Other names

Amyloid beta oligomersAmyloid beta fibrilsAβ plaquesAmyloid beta aggregates

Antibody-mediated clearance of amyloid beta aggregates, inhibition of amyloid beta aggregation