Amyloid Deposits (N/A)

Amyloid deposits are abnormal, extracellular accumulations of proteinaceous fibrillar material exhibiting a characteristic β-sheet secondary structure. These insoluble deposits form when normally soluble proteins misfold and aggregate into highly ordered fibers known as amyloid fibrils. Amyloid deposition is a hallmark of several diseases collectively termed amyloidoses, including Alzheimer's disease, cardiac amyloidosis, type II diabetes, and spongiform encephalopathies. While some amyloids have biological roles (e.g., peptide storage), their presence generally indicates pathology.

Other names

Amyloid plaquesAmyloid fibrilsExtracellular protein aggregates

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