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Amyloid fibril protein AL
- Molecular classification
- Protein aggregate, Immunoglobulin light chain
01
Overview
Amyloid fibril protein AL is derived from immunoglobulin light chains that misfold and aggregate extracellularly as highly ordered β-sheet-rich fibers. These deposits cause tissue damage through physical disruption rather than direct toxicity from monomers or oligomers, leading to organ dysfunction in primary systemic (AL) amyloidosis.
- Other names
- AL amyloidAmyloid light chainImmunoglobulin light chain amyloid
02
Biological functions
Protein aggregationExtracellular deposition
03
Disease associations
Primary systemic (AL) amyloidosisOrgan dysfunction
04
Safety considerations
Organ toxicity due to amyloid depositionChallenges in achieving complete clearance of amyloid depositsRelapse of amyloidosis
05
Biomarkers
Monoclonal immunoglobulin light chains in serum or urinePresence of amyloid deposits in tissue biopsies
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