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Amyloid Deposit

Molecular classification: Protein Aggregate, Pathological deposit

Overview

Amyloid deposits are abnormal aggregates of proteins that accumulate in tissues and organs, disrupting their normal function. These deposits are a hallmark of a group of diseases known as amyloidoses, which can affect multiple organ systems including the heart, kidneys, liver, spleen, nervous system, and digestive tract. Amyloids are characterized by their fibrillar morphology and a cross-β-sheet secondary structure. Deposition disrupts tissue architecture and function and may lead to organ failure.

Other names: Amyloid plaquesAmyloid fibrilsAmyloid aggregates

Biological functions

Protein aggregationTissue disruptionInduction of inflammationInduction of fibrosis

Disease associations

AmyloidosisAlzheimer's DiseaseAL amyloidosisAA amyloidosisATTR amyloidosisNeurodegenerative diseaseCardiovascular diseaseRenal failure

Safety considerations

Organ damageTissue disruptionInflammationFibrosis

Biomarkers

Amyloid-beta plaques (Alzheimer's)Immunoglobulin light chains (AL amyloidosis)Serum amyloid A (AA amyloidosis)Transthyretin (ATTR amyloidosis)

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