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Target intelligence / Profile preview
Amyloid-beta Plaque (Aβ Plaque)
- Target
- Aβ Plaque
- Molecular classification
- Aggregate, Extracellular deposit
01
Overview
Amyloid-beta plaques are extracellular deposits primarily composed of aggregated amyloid beta peptides (Aβ), which accumulate in the brain and are a defining neuropathological hallmark of Alzheimer's disease. They exist in different forms, with dense-core plaques being more closely associated with neurodegeneration and cognitive decline. Therapeutic strategies targeting Aβ plaques aim to reduce their formation, promote their clearance, or neutralize their toxic effects.
- Other names
- Amyloid plaquesNeuritic plaquesSenile plaquesAmyloid beta (Aβ) plaques
02
Mechanism of action
Target for therapies aiming to reduce Aβ production, aggregation, or promote clearance.
03
Biological functions
AggregationNeuroinflammationSynaptic dysfunctionNeuronal death
04
Disease associations
Alzheimer's DiseaseNeurodegenerative disease
05
Safety considerations
ARIA (Amyloid-Related Imaging Abnormalities)Off-target effects of Aβ-targeting therapiesIncomplete understanding of plaque formation and impact on disease progression
06
Biomarkers
Plaque density on PET imagingAβ42/Aβ40 ratio in cerebrospinal fluid
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