Amyloid Pore

Amyloid pores are membrane-spanning structures formed by the oligomerization of amyloidogenic peptides, primarily amyloid-β (Aβ). These pores disrupt cellular ion homeostasis, particularly calcium, and are implicated in neurotoxicity in Alzheimer's disease. They are typically composed of small Aβ oligomers assembled into β-barrel-like structures that insert into lipid bilayers, acting as non-selective cation channels. Targeting these pores represents a therapeutic strategy for AD.

Other names

Aβ poreAmyloid-beta poreAmyloid channelAβ oligomeric poreAmyloid beta pore-forming oligomer

Inhibition of amyloid pore formation; Stabilization of amyloid-beta monomers/oligomers to prevent pore formation; Blockage of ion channel activity of amyloid pores