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Target intelligence / Profile preview
Amyloid Precursor Protein Intracellular Domain (AICD)
- Target
- AICD
- Molecular classification
- Protein fragment, Intracellular signaling molecule, Transcription factor (indirect)
01
Overview
The Amyloid Precursor Protein Intracellular Domain (AICD) is a peptide fragment generated from the proteolytic processing of the amyloid precursor protein (APP). AICD plays roles in gene regulation, intracellular signaling, protein translation, apoptosis, and cytoskeletal organization. It has been implicated in the pathophysiology of Alzheimer's disease.
- Other names
- APP Intracellular DomainAICAmyloid Precursor Protein Cytoplasmic Domain
02
Mechanism of action
Modulation of gene transcription, intracellular signaling, and protein translation through protein-protein interactions and post-translational modifications.
03
Biological functions
Gene transcription modulationSignal transductionTranslation controlApoptosis regulationCytoskeletal organization
04
Disease associations
Alzheimer's diseaseNeurodegenerative disease
05
Safety considerations
Potential for off-target effects due to broad interactionsComplexity of downstream signaling pathways makes targeted intervention challengingUncertainty regarding causative vs. secondary role in disease progression
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