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Target intelligence / Profile preview
Amyloid Precursor Protein Secretase (APP Secretase)
- Target
- APP Secretase
- Molecular classification
- Enzyme, Protease, Aspartyl Protease, Multi-protein complex
01
Overview
Amyloid precursor protein secretases comprise several membrane-associated proteolytic enzymes that regulate critical steps in neural health via controlled cleavage events on APP—with dysregulation directly linked to Alzheimer's disease pathogenesis through overproduction/accumulation of toxic amyloids.
- Other names
- α-Secretaseβ-Secretaseγ-SecretaseBACE1BACE2Presenilin complexη-Secretaseθ-Secretasemeprin-β-secretaseδ-secretase
02
Mechanism of action
Inhibition of secretase activity to reduce Aβ production
03
Biological functions
Amyloid precursor protein (APP) processingAmyloid-beta (Aβ) peptide generationIntramembrane proteolysisSignal transduction
04
Disease associations
Alzheimer's diseaseNeurodegenerative disease
05
Safety considerations
Off-target effects due to broad substrate specificityPotential disruption of essential physiological functionsCognitive worseningGastrointestinal side effectsSkin cancer
06
Biomarkers
Aβ peptide levels in cerebrospinal fluid (CSF)Aβ plaques in brain imaging (PET scans)
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