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Target intelligence / Profile preview
AN1-type zinc finger protein 1 (ZFAND1)
- Target
- ZFAND1
- Molecular classification
- Other (Zinc finger domain-containing protein)
01
Overview
AN1-type zinc finger protein 1 (ZFAND1) is a cytoplasmic protein containing two AN1-type zinc finger domains and a C-terminal ubiquitin-like domain. It functions in the regulation of cytoplasmic stress granule turnover by mediating the clearance of stress granules (SGs) induced by arsenite and other proteotoxic insults. ZFAND1 interacts with the 26S proteasome and the ATP-dependent chaperone VCP/p97, recruiting them to SGs to facilitate degradation of defective ribosomal products and prevent persistence of aberrant, disease-associated SGs. Loss or mutation of ZFAND1 disrupts normal SG turnover, contributing to proteostasis defects linked to neurodegeneration and cancer. ZFAND1 is not a receptor, enzyme, transporter, or classical drug target, and there are currently no known drugs or clinical biomarkers associated specifically with this protein.
- Other names
- ZFAND1FLJ14007Zinc finger AN1-type-containing protein 1AN1-type zinc finger protein 1zinc finger, AN1-type domain 1ZFAN1
02
Biological functions
Regulation of cytoplasmic stress granule turnoverProtein homeostasis/proteostasisRecruitment of the 26S proteasome and ATPase VCP (p97) to stress granules
03
Disease associations
Neurodegenerative disease (implicated in stress granule clearance defects and IBMPFD/ALS)Cancer (mutations associated with ovarian carcinoma and breast cancer)Other (Inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; Spastic paraplegia 8, autosomal dominant)
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