AN1-type zinc finger protein 2B (ZFAND2B)

AN1-type zinc finger protein 2B (ZFAND2B) is a zinc finger protein characterized by a conserved AN1 domain containing six cysteine and two histidine residues that coordinate two zinc ions[2][5]. It plays a key role in protein homeostasis by facilitating the ubiquitin-mediated proteasomal degradation of misfolded or aberrant proteins, especially those which fail to properly translocate to the endoplasmic reticulum[3][4]. ZFAND2B is implicated in quality control processes that prevent the accumulation of toxic proteins, and it indirectly regulates signaling pathways such as the insulin-like growth factor receptor pathway by modulating receptor steady-state levels. It has been considered a potential therapeutic target due to its central role in these processes and potential links to protein misfolding disorders and metabolic diseases[4]. There are no established drug interactions or approved targeted therapies, but its biochemical function as a regulatory component of proteasomal degradation systems makes it an attractive subject for research into new therapies for conditions related to protein quality control failure.

Other names

Arsenite-inducible RNA-associated protein-like proteinZFN2B_HUMAN

Modulation of proteasome activity. Disruption or enhancement of protein translocation and degradation by targeting ZFAND2B.