Anaerobic bacterial DNA replication

Anaerobic bacterial DNA replication is the process by which bacteria replicate their DNA in the absence of oxygen, enabling anaerobic bacterial cell division and propagation. This process is catalyzed by a complex ensemble of enzymes—including the initiator protein DnaA, the DNA helicase DnaB (with DnaC as loader in Gram-negatives), primase DnaG, the primary replicative DNA polymerase III (Pol III), and additional accessory proteins[1][2][6][7][8]. Although the overall mechanism is conserved between aerobic and anaerobic bacteria, protein activity and regulatory environments differ in the absence of oxygen[5]. The DNA replication machinery is an established antimicrobial drug target (e.g., inhibitors of DNA gyrase/topoisomerase or nitroimidazole antibiotics), but "anaerobic bacterial DNA replication" as a term does not designate a unique molecular entity[9].

DNA synthesis inhibition, Disruption of DNA structure, DNA strand break induction