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Anandamide Reuptake Transporter

Molecular classification
Transporter, Membrane Transport Protein (putative)
01

Overview

The anandamide reuptake transporter is a putative molecular entity involved in the facilitated uptake of anandamide, a key endogenous cannabinoid neurotransmitter. It plays a crucial role in terminating anandamide signaling by rapidly removing it from the extracellular space. While pharmacological evidence supports its existence, the precise molecular identity remains unknown. Inhibition of this transporter elevates extracellular anandamide levels, suggesting potential therapeutic applications in various conditions, but further research is needed to address safety concerns and confirm its molecular identity.

Other names
Anandamide membrane transporterAMT
02

Mechanism of action

Inhibition of anandamide reuptake, leading to elevated extracellular anandamide levels

03

Biological functions

Endocannabinoid signaling terminationAnandamide reuptakeRegulation of extracellular anandamide levels
04

Disease associations

Pain managementNeuroprotectionAnxiety disordersObesityMetabolic syndrome
05

Safety considerations

Off-target effects of inhibitorsLack of definitive molecular identificationPotential for dysregulation of the endocannabinoid system
06

Interacting drugs

AM404

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