Anaphase-promoting complex (APC/C)

The Anaphase-promoting complex (APC/C) is a multi-subunit E3 ubiquitin ligase that serves as a master regulator of the eukaryotic cell cycle, particularly during the transition from metaphase to anaphase (NIH, 2023; UniProt, 2024). By targeting specific substrates like securin and B-type cyclins for degradation via the 26S proteasome, the APC/C facilitates the separation of sister chromatids and the exit from mitosis (Wikipedia, 2024). In oncogenesis, the complex is often dysregulated, leading to aneuploidy and chromosomal instability, making it a focal point for cancer research (Nature Reviews Molecular Cell Biology, 2020). Therapeutic strategies involve small-molecule inhibitors such as ProTAME and Apcin, which aim to induce mitotic arrest and subsequent cell death in rapidly dividing cancer cells (PubMed, 2021). However, the essential role of APC/C in normal cell division presents a narrow therapeutic window and significant safety concerns regarding systemic toxicity and potential genomic damage (Journal of Biological Chemistry, 2022).

Other names

CyclosomeAPC/CAnaphase-promoting complex/cyclosomeE3 ubiquitin-protein ligase APC complex

E3 ubiquitin ligase inhibition; prevents the degradation of cell cycle regulators (Securin, Cyclin B1), leading to mitotic arrest and subsequent apoptosis.