Anaphase-promoting complex subunit 1 (ANAPC1)

Anaphase-promoting complex subunit 1 (ANAPC1) is a core component of the **anaphase-promoting complex/cyclosome (APC/C)**, a large multi-subunit E3 ubiquitin ligase critical for cell cycle control. The APC/C mediates ubiquitination and proteasomal degradation of key regulatory proteins, such as cyclins and securin, ensuring timely progression through mitosis and transition from metaphase to anaphase[1][2][3][4]. ANAPC1 is one of at least ten essential subunits that together form the molecular scaffold and catalytic core of the APC/C, working in concert with regulatory subunits (notably Cdc20 and Cdh1) to confer substrate specificity and cell cycle checkpoint control[2][3]. Dysregulation of APC/C or its subunits, including ANAPC1, may contribute to oncogenesis due to failures in regulated cell division[2][3]. There are currently no drugs specifically targeting ANAPC1, but inhibition of the overall APC/C complex is a topic of therapeutic interest, particularly in cancer research[3].

Other names

ANAPC1APC1MCPRTSG24anaphase promoting complex subunit 1

Drugs targeting the APC/C (as a complex) generally act as E3 ubiquitin ligase inhibitors, blocking the targeted degradation of cell cycle regulators Mechanisms involve inhibition of ubiquitin ligase activity or disruption of coactivator binding (Cdc20/Cdh1)