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Anaphase-promoting complex subunit 7 (ANAPC7)
- Target
- ANAPC7
- Molecular classification
- Enzyme (component of E3 ubiquitin ligase complex), Protein complex subunit, Tetratricopeptide repeat-containing protein
01
Overview
Anaphase-promoting complex subunit 7 (ANAPC7) is a protein that comprises a part of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase complex essential for regulation of the cell cycle, particularly the transition from mitosis to G1 phase[1][3][6]. ANAPC7 contains tetratricopeptide repeat (TPR) domains and facilitates protein-protein interactions necessary for the ubiquitination and degradation of cell cycle regulators such as B-type cyclins[1][2][3][6]. By mediating substrate recognition and ubiquitin conjugation, ANAPC7 is indispensable for proper mitotic progression, cellular proliferation, and tissue homeostasis. Dysregulation or mutation of ANAPC7 and its parent complex has been implicated in various diseases, including cancer and neurodevelopmental disorders[3][7].
- Other names
- APC7Cyclosome subunit 7FERBONanaphase-promoting complex subunit 7cyclosome subunit 7
02
Mechanism of action
Inhibition or modulation of APC/C activity (potential, as part of E3 ligase); Blocks cell cycle progression by preventing substrate ubiquitination
03
Biological functions
Cell cycle regulationUbiquitin-mediated proteolysisProtein ubiquitinationMitosis and G1 phase progression
04
Disease associations
CancerNeurodevelopmental disorder (Ferguson-Bonni Neurodevelopmental Syndrome)Leukemia, acute myeloid
05
Safety considerations
Potential disruption of cell cycle control if inhibitedPossible toxicity due to interference with ubiquitin-proteasome system
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