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Target intelligence / Profile preview
Anaplastic Lymphoma Kinase (None)
- Target
- None
- Molecular classification
- Receptor Tyrosine Kinase, Insulin Receptor Superfamily
01
Overview
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in cell growth and differentiation. Aberrant ALK activity, often due to gene fusions or activating mutations, drives oncogenesis in several cancers, including lymphoma, lung cancer, and neuroblastoma. It functions as a "dependence receptor", where, without ligand, it induces caspase‐3 mediated apoptosis. Small-molecule inhibitors targeting ALK are used clinically for treating ALK-positive cancers.
- Other names
- ALK tyrosine kinase receptorCD246
02
Mechanism of action
Small-molecule inhibitors that bind to the ATP-binding site of the ALK kinase domain, preventing its activation and downstream signaling.
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosis regulationNerve cell development
04
Disease associations
CancerAnaplastic large-cell lymphomaNon-small cell lung cancerNeuroblastomaDiffuse large B-cell lymphomasInflammatory myofibroblastic tumors
05
Safety considerations
Resistance to ALK inhibitorsDevelopment of secondary mutationsOff-target effects of inhibitorsCentral nervous system penetration of inhibitors
06
Interacting drugs
Small-molecule ALK inhibitors (e.g., Crizotinib, Ceritinib, Alectinib, Brigatinib, Lorlatinib)
07
Biomarkers
ALK rearrangements (e.g., EML4-ALK)ALK fusion genes (e.g., NPM-ALK)ALK activating mutationsALK protein expression
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