Target intelligence / Profile preview

Anaplastic Lymphoma Kinase Receptor Tyrosine Kinase (ALK)

Target: ALK
Molecular classification: Receptor Tyrosine Kinase

Overview

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein encoded by the ALK gene located on chromosome 2p23.2–p23.1. It plays a role in neural development, but its aberrant activation due to chromosomal rearrangements, mutations, or amplification is implicated in various cancers, including NSCLC, ALCL, and neuroblastoma. Several small-molecule inhibitors targeting ALK are clinically used.

Other names: CD246

Mechanism of action

Small-molecule inhibitors targeting aberrant forms of ALK; ATP-binding site inhibitors; PROTACs promoting degradation

Biological functions

Signal transductionCell growthCell proliferationCell differentiationRegulation of nerve cell proliferation and maturation (embryonic development)

Disease associations

CancerAnaplastic Large Cell LymphomaNon-Small Cell Lung CancerNeuroblastomaDiffuse large B-cell lymphomasInflammatory myofibroblastic tumorsEsophageal squamous cell carcinomasGlioblastomaBreast cancer

Safety considerations

Resistance mechanisms to ALK inhibitorsSpecific side effects of individual ALK inhibitors

Interacting drugs

Crizotinib

4 more in the full profile.

Biomarkers

NPM–ALK fusion (ALCL)EML4–ALK fusion (NSCLC)ALK point mutations/amplification (Neuroblastoma)

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